e
Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis [2]
44 mg/mL: ALOGPS: logP-0
Medication Guide WARNING: SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRAL NERVOUS SYSTEM
The solubility of Ofloxacin at the selected conditions was calculated from the slope of the calibration straight lines constructed from the absorbance of the standard
The solubility of ofloxacin did not change considerably by the solvent treatment technique indicating the lack of major crystalline changes
Ofloxacin is in a class of antibiotics called fluoroquinolones
Ofloxacin
In this work, solubilities of OFL and sorption of OFL on three multi-walled CNTs at different pHs and different methanol volume fractions (f(c)) of methanol/water mixture solutions were systematically measured
97: R4 R = Peer Ofloxacin fluoroquinolone antibiotic; CAS Number: 82419-36-1; Synonyms: Dextrofloxacin; find Sigma-Aldrich-O8757 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich solubility
Ofloxacin (OFL) is an antibiotic with a wide range of bacterial infections but its low water solubility and photo stability restricts its applications, so improve its solubility and stability is a challenge
15, 310
slightly soluble
The study focusses on the effect of solubility and intrinsic dissolution rate on the pharmaceutical salt of ofloxacin, a new generation fluoroquinolone antibacterial marketed drug, with the organic acid coformer, diphenic acid produced via mechanochemical synthesis using liquid assisted grinding method
41): Water Solubility at 25 deg C (mg/L): 6
Solubility Ofloxacin is freely soluble in acetic acid, slightly soluble in water, methanol, ethanol or acetone8
The equilibrium solubility of norfloxacin and ofloxacin in scCO 2 was determined at 313
3 MPa and according to the static method previously detailed in the experimental section
The objectives of this research was to investigate the effects of pH and ionic strength on solubility profile of ofloxacin
268 Ofloxacin fluoroquinolone antibiotic; CAS Number: 82419-36-1; Synonyms: Dextrofloxacin; find Sigma-Aldrich-O8757 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich solubility
Gram The solubility of ofloxacin did not change considerably by the solvent treatment technique indicating the lack of major crystalline changes
S
Least-Square Fitting Analysis using Henderson-Hasselbalch equation for amphoteric compound was insufficient to describe ofloxacin solubility process in a
Because of its sparing solubility in water, the dissolution of ofloxacin from its dosage form after oral administration which is an important factor related to its bioavailability, is usually the rate-limiting step in the absorption process (Bates et al