5 year old pup just got diagnosed with ARVC and was given 250mg of Mexiletine 2x a day and 40g of Sotalol 2x a day
Sotalol is a commonly used antiarrhythmic drug that may alter ventricular
Animals: 49 Boxers
A single dose of sotalol may cause a mild decrease in LV systolic function in
The caption reads: "I am convinced she is inhabited by an unknown alien
I would guess that there is a possible risk interaction with the two, or maybe something as What is sotalol? Sotalol (brand names: Betapace®, Sorine®, Sotylize®, Sotamol®, Sotacor®, Rylosol®, Linsotalol®) is a beta-adrenergic blocker used to treat abnormal heart rhythms, most often those that cause abnormally fast heart rates
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Unfortunately, in Brazil, mexiletine has not been available in the last 2-3 years
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Boxers presented for syncope without DCM are treated with sotalol (1–3 mg/kg, PO, every 12 hours) or a combination of mexiletine (5–10 mg/kg, PO, every 8 hours) and atenolol (12
Two main classes are beta-blockers (such as atenolol, sotalol, carvedilol) and calcium-channel blockers The administration of a β-blocker or sotalol to such dogs can aggravate or precipitate neurocardiogenic bradycardia-related syncope
Quinidine What is Mexiletine
pp 748
14, 15 Its anti-arrhythmic efficacy has been demonstrated both in boxer dogs with spontaneous VA 6 as well as human patients with VA that were refractory to class I anti-arrhythmics
He has taken Sotalol in the past
Sotalol - 80mg
No dog experienced an adverse event post-sotalol, including dogs with systolic dysfunction or atrial enlargement
Contact your veterinarian if you see these signs
It has approximately 30% of the beta blocking potency of propranolol, so has less potential for negative inotropic effects than Class II beta blockers
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