Best evidence for efficacy in treating post-traumatic agitation with minimal side effects per Cochrane review [24] shown to reduce agitation intensity and need for physical restraints [25] Also improves restlessness and disinhibition [14] iii
Considering amantadine’s affinities in vitro and the expected concentration at targets at therapeutic doses in humans, the following primary targets seem to be most
Amantadine is a long-known drug, originally approved for treatment of influenza A and Parkinson`s Disease
184 patients with prolonged disorders of consciousness (28–112 days after injury) after traumatic brain injury received either amantadine (up to
Murray ABSTRACT: We carried out a double blind control study of fatigue in 32 patients with multiple sclerosis
The quality and outcomes of the studies were evaluated
Many textbooks report amantadine as a first‐choice drug for MS‐related fatigue because of published randomised controlled trials (RCTs) showing some benefit
Many generic formulations of amantadine are available
Environmental: Excessive stimulation, Temperature, Restraints -“ICU Syndrome” : acute state of confusion seen even in Amantadine i
Reviews of the treatment of spasticity and pain when due to other aetiologies were also sought
Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended because of widespread drug resistance
Amantadine (Gocovri, Osmolex), modafinil (Provigil) and methylphenidate (Ritalin) have been used to reduce MS-related fatigue
Memantine is the Amantadine is a long-known drug, originally approved for treatment of influenza A and Parkinson`s Disease
Amantadine is known to increase indirectly dopamine via antagonistic effects at the N-methyl-D-aspartate (NMDA) receptor by increasing the release and blocking the
Although the disorder itself is not neurodegenerative Extended-release tablets: Initial dose: 129 mg orally once a day in the morning
“An example of an effective breathing pattern is one where your exhale lasts longer The adverse effects included spasticity, agitation, vomiting, rash, restlessness, diarrhea, elevated liver function tests, generalised tonic clonic seizures (GTCS), constipation, Amantadine is an old drug and since its serendipitous discovery in 1969 has been abundantly used for Parkinson's disease
g
It is available in an immediate-release formulation (brand name: Symmetrel) and an extended-release formulation (brand name: Gocovri)
Since amantadine might also enhance arousal from coma due to dopamine effects,1 we initiated a therapy with amantadine starting with 100 mg/day intrave-nously, increasing the dose 100 mg per day, and switched to an enteral drug administration after reaching the maximum dose of 300 mg/day given once in the morning
Spasticity is a disruption in muscle movement patterns that causes certain muscles to contract all at once when you try to move or even at rest