Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead Sciences
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Ledipasvir is a benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection
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High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12
Show details Ottawa (ON): Canadian Agency for Drugs and Technologies in Health ; 2015 Jul
Ledipasvir and sofosbuvir is a combination medicine used to treat chronic
Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays a critical
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Harvoni (ledipasvir / sofosbuvir) interacts with a lot of common medications like famotidine (Pepcid), omeprazole (Prilosec), cholesterol-lowering statins, and HIV antiretrovirals
very slow heartbeats, chest pain, shortness of breath; confusion, memory problems; or
The use of certain abbreviations can be dangerous and lead to patient injury or death
The recommended dosage of HARVONI in adults with genotype 1, 4, 5, or 6 HCV is one tablet (90 mg ledipasvir and 400 mg sofosbuvir) taken orally once daily with or without food [see Clinical Pharmacology (12
Sovaldi is ALWAYS given in combination with other hepatitis C treatments, Harvoni is a stand-alone treatment
To date, liver failure due to CHC is still the number one indication for liver transplant in Canada []
Appendices Appendix A: Abbreviation Key APRI: AST to platelet ratio For treatment-experienced individuals, the presence of baseline RASs with greater than 100-fold reduced susceptibility to ledipasvir was associated with an SVR12 of 64
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Weight 17 to less than 35 kg: Ledipasvir 45 mg-sofosbuvir 200 mg orally once a day
Ledipasvir/sofosbuvir, in combination with ribavirin, must not be used during pregnancy by either the pregnant woman or her male partner
It may be used to treat certain genotypes of the hepatitis C virus in adults and children over the age of three
A small non adverse weight gain was In long-term follow-up at a median of 4 years after the end of treatment, a clinically meaningful decrease in MELD score of ≥3 occurred in 29% and a final MELD score of <10 was achieved in 25%
The fixed-dose combination of ledipasvir-sofosbuvir and provides an effective and well-tolerated one-pill once-a-day option for treatment of genotypes 1, 4, 5, and 6 chronic hepatitis C (HCV) infection