429626 Da; ChemSpider ID 2006532 Digoxin is toxic substance with well known cardiotoxic effect
Cardiac glycosides, including digitalis and digoxin, have long-standing use in clinical practice
The digoxin molecule is composed of a sugar and a cardenolide; its molecular formula is C 41 H 64 O 14 and its molecular weight is 780
Hazard class*
About its Science, Chemistry and Structure Digoxin (Molecule of the Month for May 2011) Foxglove, Lanoxin, Digitek, Lanoxicaps Digoxin is a purified cardiac glycoside extracted
Structure of digoxin @article{Go1980StructureOD, title={Structure of digoxin}, author={Kuantee Go and Gopinath Kartha and J
The structure of (+)-digoxin (1) was established previously by analysis of its single-crystal X-ray diffraction data, 4 with the (3’cS,4’cS) absolute configuration
It is found that the level of glycosylation affects the depth of CTS binding and that the steroid core substituents fine tune the configuration of transmembrane helices αM1–2, which is highly relevant for the understanding of physiological effects and future drug development based on cardiotonic steroids
Extract 20 ml of powdered herb with 100 ml of ethanol 70% by warming on Hot Plate for 20 min ii
A cardenolide glycoside that is digitoxin β-hydroxylated at C-12
Digoxin and digitoxin present a higher binding selectivity for α 2 and α 3 than α 1, whereas ouabain has higher binding selectivity for α 1 than α 2
Digoxin is toxic substance with well known cardiotoxic effect
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Mechanism of Action: Digitoxin and digoxin inhibit sodium–potassium activated adenosine triphosphatases (i
The drugs were extracted from whole blood or urine by SPE using Oasis HLB cartridges at alkaline pH
Joel Edwards DVM, DACVIM (Cardiology), in Small Animal Critical Care Medicine, 2009 PHARMACOLOGY
In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and explore more potent anticancer agents, a series of C 3-O-neoglycosides and C 3-MeON
This chemical increases the amount of calcium in the heart cells, which strengthens the heartbeat
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English physician William Withering is credited with discovering in Lipophilicity is markely influenced by the number of sugar residues and the number of hydroxyl groups on the aglycone part of the glycoside