When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system
It works by being converted to dopamine in the brain
The mechanisms of action of L-dopa in Parkinson's disease
Levodopa / pharmacology* Levodopa / therapeutic use Norepinephrine / physiology 10
Levodopa: The metabolic precursor of dopamine, a chemical depleted in Parkinson's disease
(as an adjunct to carbidopa/levodopa): Oral inhalation: 84 mg up to 5 times daily as needed when
In this study, we screened a large number of FDA-approved drugs and found levodopa, a drug used to treat Parkinson's disease, had an inhibitory effect on the growth of ESCC cells
Levodopa is absorbed in the small bowel and is rapidly catabolized by aromatic-L-amino-acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT)
The peripheral and central pathway of metabolism of levodopa is depicted in Fig
Levodopa-induced dyskinesia is currently thought to relate to pre- and post-synaptic changes that result in dopaminergic imbalance
Levodopa is the most reliable anti-PD drug for improvement of motor symptoms
methods