10,12 As a consequence, it is reasonable to hypothesize the toxicity of statin after coprescription of CYP3A4-metabolized Pravastatin3-4 Concentration of statins may be increased, resulting in potentially increased risk of statin-associated muscle symptoms No clinically significant interaction expected Atorvastatin and rosuvastatin should be discontinued during nirmatrelvir/ritonavir therapy; no need to hold before or after Lovastatin and simvastatin dilTIAZem food
If Paxlovid is started in a patient on a CCB, the most reasonable approach (supervised by a physician) would be to cut the dose in half and have the Yes
Starting with 30 mg four times daily, before meals and at bedtime, dosage is increased gradually (given in divided doses three or four times daily) at 1- to 2-day intervals until optimum response is obtained
When simvastatin (to lower cholesterol) and diltiazem (to control blood pressure) are given together, the blood level of simvastatin rises and the concentration of diltiazem decreases ( Life Sciences, Dec
Both Atorvastatin and Nicotinic acid can increase the risk of hepatotoxicity
Danshen may make your blood pressure too low if you take danshen with a drug used to lower blood pressure
Cardizem CD disease interactions
, pravastatin) during idelalisib therapy
Nicotinic acid might increase the risk of rhabdomyolysis when given with Simvastatin
Drug interactions are reported among 41 people who take Cardizem cd and Pravastatin sodium
This includes muscle pain, weakness, or tenderness
Diltiazem did not affect the oral AUC, C max, or half-life of pravastatin
Reference: 1) MHRA Drug Safety Update (August 2012)
Calcium channel blockers, other cholesterol medications, and grapefruit juice can also interact with simvastatin
2011;83(6):711–716
Calcium Channel Blockers ↑ concentrations expected Concentrations of nifedipine, amlodipine, diltiazem, and verapamil are increased roughly 2-fold