A high level of the drug can raise your risk of side effects from digoxin
2004;
42–44 Alcohol ingestion appears to have variable effects on the antihypertensive effects of CCBs, and intake should be limited
1 These studies have led to a better understanding of how drugs are metabolized and transported within
The degree of interaction depends on drugYgrapefruit juice interactions and those drugs most likely to be affected by the ingestion of grapefruit juice
477-483, 10
We agree that grapefruit juice may produce clinically significant interactions with a few drugs
Grapefruit juice is a well-recognised inducer of CYP1A2
The effect of grapefruit juice on digoxin C max (-45% to +41%) and AUC 0–4 (-29% to +25%) varied substantially among subjects and was inversely correlated with the values during the water phase
It is unclear whether this applies to intestinal P-gp, for which digoxin is not considered to be a sensitive probe
Grapefruit can raise the levels of sildenafil There is a potential drug interaction with grapefruit juice and amlodipine
Grapefruit juice has been shown to increase the AUC of digoxin slightly
Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans
More than half (58%) took supplements that had potential interactions with warfarin, amiodarone, sotalol, or digoxin