Converting From: Betamethasone (IV) Cortisone (PO) Dexamethasone (IV or PO) Hydrocortisone (IV or PO)
Dose equivalent to 5 mg of prednisolone; Betamethasone: 750 micrograms: Cortisone acetate: 25 Short-acting products such as hydrocortisone are the least potent
Prednisone 5 4 0
prednisone: What’s the difference? Methylprednisolone and prednisone are corticosteroid medications used to treat
Medical Answers Prednisone vs Prednisolone - What's the difference? Medically reviewed by Carmen Pope, BPharm
Prednisone – is an anti-inflammatory that suppresses the immune system, it is used to treat allergic disorders, skin conditions, arthritis etc
4 mg methylprednisolone is equivalent to 5 mg prednisolone
5 Both methylprednisolone and prednisone can interact with other drugs
Plasma half-life does not accurately reflect a corticosteroid's duration of action in vivo
In addition, inter-conversion is present between both substances and this varies
Prescription only
[37] [38] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value
Medrol is a tablet of methylprednisolone available as 2, 4, 8, 16 or 32-milligram doses
They are not equivalent, 4mg of Methylprednisolone is equivalent to 5mg of Prednisone
Drug Equivalent Dosage (mg)* Betamethasone 0
Because of this, the side effects of prednisone and prednisolone are also similar
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