Intravenous verapamil pharmacokinetics

Due to the higher CL of (-)-verapamil the extraction ratio of the (-)-isomer is substantially higher. Intravenously administered verapamil hydrochloride has been shown to be rapidly metabolized

2024-03-28
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  1. Verapamil counteracts the effects of quinidine on AV conduction
  2. and Ekelund, L
  3. Eur J Clin Pharmacol
  4. Protein binding for the two isomers was also different
  5. 86 l/hr/kg
  6. We report the pharmacokinetics of escalating doses of verapamil
  7. 1080/00498254
  8. III
  9. S
  10. 6 yr)
  11. v
  12. 5 and 10 mg of (-)- and 5, 25 and 50 mg of (+)-verapamil
  13. Methods
  14. 2
  15. Patients: Nine patients (age range 31 to 57 yrs) with