Clopidogrel is a widely used antiplatelet agent for the secondary prevention of cardiovascular events in patients with stable coronary heart disease, acute coronary syndromes and ischemic stroke
Since clinical studies indicate that atorvastatin inhibits the antiplatelet activity of Background
[5,6] The enzyme cytochrome P450 3A4 may also be involved in the conversion
Like many medicines, how well the medicine works and side effects are different from person to person
A number of polymorphisms in the CYP2C19 gene have been shown to decrease
There are different CYP2C19 gene versions, or variants, and each has a different effect on how well clopidogrel is metabolized in the body
It is not known whether initiating an inhibiting SSRI while treated with clopidogrel will also
1), Clinical Pharmacology (12
ketoconazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism
Aims: Clopidogrel is an antiplatelet drug primarily used to treat or prevent acute ischemic stroke (IS) or myocardial infarction (MI)
Patients receiving clopidogrel are often treated with selective serotonin reuptake inhibitors (SSRIs) for co-existing depression
CYP2C19 and CYP3A4/5 are the principal contributors in the two-step hepatic oxidation of clopidgrel