Paroxysmal sympathetic hyperactivity (PSH) is commonly also referred to as dysautonomia or “storming” and is a syndrome consisting of paroxysmal
The most commonly used drugs for treatment of PAID are morphine sulfate, bromocriptine mesylate, propranolol hydrochloride, clonidine hydrochloride, lorazepam, and
Though some studies have provided guidelines for the management of PSH like symptomatic management and use of drugs like clonidine, bromocriptine
On the basis of these findings, we suggest that not only receptor supersensitivity of dopaminergic neurons but also involvement of noradrenergic
Clonidine, naloxone and CB-154 plus naloxone lowered insulin plasma levels; CB-154 alone
It manifests with recurrent episodes of excessive sympathetic activity that start rapidly, are often
Nipple discharge • Clonidine stimulates alpha 2-adrenergic receptors in the brain resulting in reduced sympathetic outflow from the CNS and decreased peripheral resistance, renal vascular resistance, heart rate, and blood pressure Gabapentin • Centrally acting • GABA agonist • Treats spasticity and allodynic response Bromocriptine Clonidine decreases central sympathetic outflow from the hypothalamus and ventrolateral medulla and may stimulate sympathetic inhibition in the brainstem [54], [59]
Conclusions: There is a direct association between craving and cocaine use, underscoring craving as an important treatment target for promoting abstinence among persons with cocaine use disorder
Best evidence for efficacy in treating post-traumatic agitation with minimal side effects per Cochrane review [24] shown to reduce agitation intensity and need for physical restraints [25] Also improves restlessness and disinhibition [14] iii
Parkinson's disease
Both Bromocriptine and Clonidine can increase the risk of hypotension
dosing of bromocriptine
Though some studies have provided guidelines for the management of PSH like symptomatic management and use of drugs like clonidine, bromocriptine, benzodiazepines, and gabapentin, strict management guidelines are not established and exact incidence in pediatric population is not determined
Patches not usually effective in diaphoretic patients, can take up to 72 hours to reach steady-state
Bromocriptine is a medication currently used in the management and treatment of type 2 diabetes mellitus
Either increases toxicity of the other by unspecified interaction mechanism
Avoid or Use Alternate Drug
The Clonidine Suppression test has been used to diagnose pheochromocytoma and those paragangliomas that may secrete epinephrine, norepinephrine, or both