With
Absorption: The estimated oral bioavailability of immediate release metoprolol is about 50% because of pre-systemic metabolism which is saturable
Side effects
The bioavailability of a single dose is approximately 50%, increasing to approximately 70% during repeated administration
Metoprolol can be taken at either morning or night, and it’s best to take it with a meal
Distribution
The peak plasma levels following once-daily administration of TOPROL-XL average one-fourth to one-half the peak plasma levels obtained following a
“Caffeinated products, such as coffee, have the ability to decrease the effectiveness of metoprolol,” Dr
Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp)
Metoprolol has been shown to increase post-implantation loss and decrease neonatal survival in rats at oral dosages of 500 mg/kg/day, i
Plasma levels following oral administration, however, approximate 50% of Metoprolol is a racemic mixture of R- and S-enantiomers
Although β-blockers can help lower the heart rate, they also have a negative inotropic effect and can decrease left ventricular contractility [
Metoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins)
52 L/min (95% C
3 A
Effect of food Compared to fasted state administration, high-fat, high-calorie meal (54
Absorption
longer time to peak and significantly lower