Pregnancy and Lactation
Written by ASHP
Pregnancy & Breastfeeding
Initially 20 mg/hour, then increased if necessary to 40 mg/hour after 30 minutes, then increased if necessary to 80 mg/hour after 30 minutes, then increased if necessary to
Generic name: labetalol (oral/injection) [ la-BAY-ta-lol ] Brand names: Trandate, Normodyne
Trandate
Labetalol may be used to lower blood pressure
Find medical information for labetalol on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures
Labetalol is a medicine which works on your heart and blood vessels
Emergency treatment of hypertension
Since the full antihypertensive effect of labetalol hydrochloride tablets are usually seen within the first 1 to 3 hours of the initial dose or dose increment, the assurance of a lack of an exaggerated hypotensive response can be
Maintenance dose: 20,000 to 40,000 units per 24 hours by continuous IV infusion
If it continues for a long time, the heart and arteries may not function properly
doses greater than the normal antiasthmatic dose of beta
07 mg/kg orally once a day (Maximum initial dose is 5 mg once a day) Maintenance dose: Dosage should be adjusted according to blood pressure response at 1 to 2 week intervals
The recommended initial dose is 200 mg, followed in 6 to 12 hours by an additional dose of 200 or 400 mg, depending on the blood pressure
High blood pressure adds to the workload of the heart and arteries
Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
Labetalol Pregnancy Warnings-Animal studies have failed to reveal evidence of teratogenicity, although an increased incidence of fetal resorption was demonstrated in some studies at doses approximating the maximum recommended human dose
Dosing information for all beta blocker products, including combination products with thiazide diuretics and angiotensin receptor blockers
Severe Hypertension Bolus Injection For rapid reduction of blood pressure, give 50mg over at least one minute
Subsequent oral dosing with labetalol HCl tablets should begin when it has been established that the supine diastolic blood pressure has begun to rise