The absolute bioavailability of ITR oral solution after oral administration
Complete pharmacokinetic results for the compounded capsule were
Itraconazole bioassay was performed on serum/plasma from 95 dogs and
Methods The pharmacokinetics of ITR were studied in eight healthy, fasted cats after a single intravenous (IV) and oral (PO) administration at a dose of 5 mg/kg, in a two-period crossover design
The biliary route is the major excretory pathway for itraconazole (>80%); ~20% of the metabolites are eliminated in the Average ratios of compounded and generic formulations to the reference formulation of itraconazole for AUC were 5
A test of bioequivalence using 2 one-sided tests and 90% confidence intervals did not meet bioequivalence criteria for either formulation
Background Itraconazole is commonly used for treatment of systemic and cutaneous mycoses in veterinary medicine
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MethodsThe pharmacokinetics of ITR were studied in eight It is recommended not to use compounded Itraconazole products unless prepared from commercial capsules or documented bioavailability and stability are provided” (Plumb 561)
Comparison of absorption characteristics of oral reference and compounded itraconazole formulations in healthy
Fowler L, Papich M, Whittemore J
Itraconazole is commonly used to treat systemic fungal infections in dogs, but problems exist with absorption and cost
When the parent compound undergoes glucuronidation the default factor of 4
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