Summary
Each patient with an ileostomy requires assessment of their medication regimen for the purpose of identifying potential medical absorption issues
A recent study assessed thyroidstimulating hormone (TSH) and levothyroxine dosage in 5426 outpatients who had been prescribed levothyroxine, along with drugs that can impair levothyroxine absorption (ie, antacids, iron, sucralfate, cholestyramine, orlistat, sevelamer, and proton pump inhibitors) or drugs that can affect levothyroxine metabolism
8), and Bupropion (Oral Route) Bupropion is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression
Bupropion is metabolized to three active metabolites once in the body, each with varying durations of action
Doses above 300 mg of bupropion hydrochloride extended-release were not assessed in the SAD trials
Studies of bupropion in rats, dogs, and normal volunteers showed that bupropion was rapidly and completely absorbed, widely distributed in tissues, and metabolized extensively prior to its excretion
For other metabolites, a minimal PBPK model were used to describe their distribution
Common side effects reported in studies of major depressive disorder include weight loss, loss of appetite, dry mouth, skin rash, sweating, ringing in the ears, shakiness, stomach pain, agitation, anxiety, dizziness, trouble sleeping, muscle pain, nausea Going through alcohol withdrawal while taking Wellbutrin also increases your risk of having a seizure along with other serious side effects, including: severe shaking and tremors
Several drugs including diuretics and proton-pump inhibitors can cause magnesium loss and hypomagnesemia