Treatment of hospital-acquired pneumonia with linezolid or vancomycin: a systematic review and meta-analysis - PMC
Presenting symptoms of pneumonia are typically cough, pleuritic chest pain, fever, fatigue, and loss of appetite
guidelines
Linezolid Pediatric Pneumonia Study Group
Pneumococcal (noo-muh-KOK-uhl) disease is an infection caused by bacteria called Streptococcus pneumoniae (also known as pneumococcus)
About linezolid
Review
pneumoniae pose threats and the bacteria are notorious causes of meningitis, pneumonia and bloodstream infections
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Up to 40% of these infections were caused by
Some authorities recommend the use of an antibiotic that inhibits toxin production, such as linezolid
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The mortality rate of bacterial meningitis approaches 100 percent and, even with optimal therapy, there is a high failure rate
Linezolid does not have approval for the
A recent prospective, randomized, double-blind multicenter trial compared linezolid to vancomycin for the treatment of hospital-acquired pneumonia (HAP) or health-care-associated pneumonia (HCAP) due to proven MRSA
Retrospective studies suggest a mortality benefit among patients treated with azithromycin, even in pneumococcal pneumonia sensitive to beta-lactams
In
Linezolid is categorized as pregnancy Category C, and there is limited experience in pregnancy, but it is a protein synthesis inhibitor, so it should also be avoided unless no other alternative therapy is available
The diagnosis
7 Because pneumococcal pneumonia is the most common form of CAP, empiric antimicrobial therapy must provide coverage of S pneumoniae, considering penicillin-resistant strains