Parenteral therapy should be IV
1
As a result of its mass production, broad-spectrum coverage, and ability to penetrate into tissues efficiently, chloramphenicol was historically used to treat a wide range of infections, from meningitis to typhoid fever to
Pharmacokinetics Indications Contraindications Use During Pregnancy and Breastfeeding Adverse Effects Chloramphenicol is an antibiotic that is primarily bacteriostatic
Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3
It has a long clinical
Interferes with the formation of the initiation complex between 50S and 30S subunits and
Chloramphenicol works by preventing bacteria from The same mechanism is responsible for the resistance to phosphomycin and chloramphenicol [5, 47]
As mentioned, regardless of the type of change, the final effect is always the same, a decrease in the affinity of Chloramphenicol is one such antibiotic which inhibits translation in a wide range of gram-positive and gram-negative bacteria as well as in mitochondria, but not in the cytoplasm of eukaryotic cells
It was isolated by David Gottlieb and introduced into clinical practice under the trade name Chloromycetin and was widely used in the 1950s
Soon afterwards, its structure was elucidated and it became the first antibiotic to be synthesized by chemical means ( Controulis et al
Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum
Use
Target site modification leading to aminoglycoside resistance occurs via the action of 16S rRNA methyltransferases (RMTs)
1–5 One such class of antibiotics is the phenicols, which includes the natural product chloramphenicol (CAM)
These drugs may cause gastrointestinal irritation, phototoxic dermatitis, diarrhea, vestibular damage, and hepatotoxicity in pregnant women