John's wort (SJW), a herbal medicine with anti‐depressant effects, interacting with other drugs
A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
John’s wort is a flowering herb that may be an alternative to conventional antidepressants for mild to moderate depression, particularly for people not taking other
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John’s wort such as hyperforin, hypericin, pseudo-hypericin, and flavonoids are involved in inhibition of monoamine oxidase, binding to brain benzodiazepine receptors, and inhibition of serotonin reuptake Antidepressants
May interact with several other drugs including other antidepressants, tramadol, bupropion, diuretics, St John's Wort, and drugs that prolong the QT interval (such as pimozide or St
Doctors will typically advise that you do not take St
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In a randomised double-blind comparative trial, the antidepressant efficacy of a daily dose of 800 mg of the St
John's wort, certain antidepressants (including other SSRIs such as citalopram/paroxetine, SNRIs such as duloxetine/venlafaxine Fluoxetine hydrochloride is a white to off-white crystalline solid with a solubility of 14 mg/mL in water
The Pulvules also contain starch, gelatin, silicone, titanium dioxide, iron oxide, and other inactive
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John’s wort with certain antidepressants or other drugs that affect serotonin, a substance produced by nerve cells, may lead to increased serotonin-related side effects, which may be potentially serious
The objectives of this review are to (1) evaluate the efficacy and safety of SJW in adults with MDD compared to placebo and active comparator and (2) evaluate whether the effects vary by severity of MDD
Mood elevation