Amlodipine has low renal clearance (7 mL/min/mg) and long half-life (35–50 h) and duration of action, which allows it to sustain its anti-hypertensive effect for more than 24 h
Jul 30, 2022 · Mean plasma half-life values from single-dose studies were 35 h in humans (cf nifedipine, ∽2 h), 30 h in dogs, 3 h in rats, and 11 h in mice
In patients with cirrhosis, elimination half-life is significantly prolonged (60 vs 34 hours; p less than 0
Amlodipine is extensively metabolized in the liver (but there is no significant presystemic or first-pass metabolism) and is slowly cleared with a terminal elimination half-life of 40 to 50 hr
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Amlodipine is widely distributed in the body (volume of distribution = 21 L/kg in humans), which is the basis for the long half-life of the drug and its potential for once-daily dosing
The terminal elimination half-life of about 30–50 hours
Loop Diuretics: May enhance the hypotensive effect of Angiotensin-Converting Enzyme Inhibitors
5 mg daily or every other day in adult patients who have been on ritonavir for at least 10 days
2 Amlodipine is usually dosed on a once daily basis because of its long half-life, which is favourable for patient compliance
Excretion
Initial therapy (antihypertensive naive): Telmisartan 40 mg/amlodipine 5 mg once daily; dose may be increased after 2 weeks of therapy
Small, fragile, or elderly patients, or 3 DOSAGE FORMS AND STRENGTHS
Votes: +1
Use in Specific Populations Special Populations: Renal Function Impairment
A starting dose of 5 mg is usually Mechanism of Action
Mean plasma half-life values from single-dose studies were 35 h Amlodipine is extensively metabolised by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine
Note: Erectile function may be improved for up to 36 hours following a single dose