Of the total drug interactions, 115 are major, 317 are moderate, and 63 are minor
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Most frequently checked interactions View interaction reports for tizanidine and the medicines listed below
Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle
If any of these effects last or get worse, tell your doctor or pharmacist promptly
Levofloxacin (systemic): Drug information; Levofloxacin (United States: Not available) (oral inhalation): Drug information; Levoketoconazole: Drug information; LEVOleucovorin:
Ciprofloxacin greatly elevates plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects, mainly by inhibiting its CYP1A2
Ciprofloxacin contraindications include history of an allergic reaction and current use of the medication tizanidine (Zanaflex)
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The relevance of a particular drug interaction to a specific individual is difficult to determine
This medication belongs to a class of drugs known as quinolone antibiotics
Major: Highly clinically significant
Major: Highly clinically significant
In principle, the risk of interactions considering the profile of the drug and Paxlovid is probably very low
Keppra Interactions
Tizanidine is used for the symptomatic relief of spasticity associated with multiple sclerosis or with spinal cord injury or When levoFLOXacin as the oral solution is given with enteral (tube) feedings, levoFLOXacin may not work as well
Manufacturer advises separate administration by 2 hours
Examples of drugs that can cause interactions with tizanidine are listed below
It is important to tell your doctor UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases
an antibiotic, including ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, or others; blood pressure medicine such as clonidine, guanfacine, methyldopa; In clinical trials, the most common side effects of tizanidine were dry mouth, sleepiness, dizziness and asthenia (defined as weakness, fatigue and/or tiredness)
The first was an elderly male Common side effects may include: nausea, constipation, diarrhea; headache, dizziness; or
Levaquin side effects (more detail) This is because levofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic and fluoroquinolone antibiotics can cause serious or disabling side effects
However, Severe side effects of levofloxacin and ciprofloxacin include tendon ruptures, nerve damage, and mental health side effects
ADRs reported most often affected the nervous system and the cardiac function, especially with large tizanidine doses or drugs with CNS and cardiovascular depressant effects
The relevance of a particular drug interaction to a specific individual is difficult to determine
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
Electrolyte abnormalities (e
Major: Highly clinically significant