3-6 mg/kg, dose to be given on first day, then 3 mg/kg daily (max
In patients with impaired renal function who will receive multiple doses of fluconazole, an initial loading dose of 50 to 400 mg should be given
There is an inverse relationship between the elimination half-life and creatinine clearance
22 An initial dose of 100 mg on alternate days is recommended for patients with a GFR <10 mL/min, 15 or if what is DOSE Fluconazole IN RENAL IMPAIRMENT , what IMPORTANT DRUG INTERACTIONS Fluconazole,CLINICAL USE Fluconazole , for what can Fluconazole used for
production of active metabolite; additive effects) Use caution in proarrhythmic conditions and renal impairment Use extreme caution or avoid in congenital long-QT patients and patients with conditions that increase QT-prolongation risk Fluconazole inhibits CYP2C9, CYP2C19, and CYP3A4 isoenzymes; coadministration with drugs that are substrates if these isoenzymes may be contraindicated or Renal impairment
of fluconazole should be reduced by 50% in patients with a creatinine clearance of 11-50 mL/min
After three hours of haemodialysis session, around 50% of fluconazole is eliminated from blood
Dosing
In patients (including paediatric population) with impaired renal function who will receive multiple doses of fluconazole, an initial dose of 50 mg to 400 mg should be given, based on the Renal impairment
The manufacturer recommends a washout period of approximately 1 week (corresponding to 5-6 half-lives) after a single-dose or discontinuation of a course of treatment for women before they become pregnant
Fluconazole was approved for use in the United States in 1990 Fluconazole is cleared primarily by renal excretion as unchanged drug
fluconazole
Patients who received fluconazole were also observed to have a shorter median time (with vs
The antifungals are classified into several groups based on their structure and mechanisms of action
Use traditional dosing or consult ID pharmacy for guidance
In the elderly, normal adult dose regimens should be used if there is no evidence of renal impairment
There is an inverse relationship between the elimination half-life and creatinine clearance
DIFLUCAN prescription and dosage sizes information for physicians and healthcare professionals
(0 to 24 hours, 22%), and the fluconazole renal clearance estimates (0
Drug doses should be altered in renal disease in accordance with the predicted reduction in the clearance of the drug
(See DOSAGE AND ADMINISTRATION
Renal
In patients with preexisting renal impairment and those at risk of developing impaired renal function, pharmacokinetic properties, and the potential for
Hepatic impairment: Not studied
9%; 50 mg; 100 mg;
3–6 mg/kg, dose to be given on first day, then 3 mg/kg every 48 hours
A treatment gap exists for pediatric patients with renal impairment
14 days except in severely immunocompromised patients); for 14–30 days in other mucosal infections (e
The pharmacokinetics of fluconazole are markedly affected by reduction in renal function
18, 21 For most older people, a maintenance dose of 100 mg/day is sufficient
dose by 50% HD: give usual loading dose x1, then give usual dose 3x/wk after dialysis; PD: decr
Use caution in proarrhythmic conditions and renal impairment Use extreme caution or avoid in congenital long-QT patients and patients with conditions that increase QT-prolongation risk Fluconazole inhibits CYP2C9, CYP2C19, and CYP3A4 isoenzymes; coadministration with drugs that are substrates if these isoenzymes may be
However, alterations in renal functions might influence fluconazole clearance
After three hours of haemodialysis session, around 50% of fluconazole is eliminated from blood
1mg/kg 24 hourly
In patients with renal impairment at baseline, renal adverse events (AE), such as oliguria, anuria, doubling of serum creatinine, hypokalemia, and hyperkalemia, were reported in 54% (22/41) of patients randomized to voriconazole and in 53% (9/17) of patients on amphotericin B/fluconazole (P = 0
Brand Name: Diflucan
If creatinine clearance > 50 mL/min, use 100% recommended dose; for creatinine clearance <50 mL/min, use 50% of the recommended dose; for patients on hemodialysis, use one The need for dose adjustment based on renal function can be explained by the predominant renal excretion of unchanged fluconazole and the reduction, This is an important finding since most published research focuses on patients with impaired renal function and the associated need for RRT [5,6,7]
In patients (including paediatric population) with impaired renal function who will receive multiple doses of fluconazole, an initial dose of 50 mg to 400 mg should be given, based on the Oral fluconazole to: People with acute porphyria
No clear recommendations, but adjustment probably not necessary (<1% renal elimination) Pyrazinamide Adult 20-25 mg/kg PO q24h (Round to 500mg tablet) 40 to 55 kg: 1,000 mg once daily 56 to 75 kg: 1,500 mg once daily CrCl <30 or HD: 25-35 mg/kg three times weekly
No adjustments in single dose therapy are necessary
UK Renal Pharmacy Group Foreword by Dr Aine Burns radcliffe Publishing Oxford • New York