The pharmacokinetics of the enantiomers of atenolol, a hydrophilic cardioselective β‐adrenoceptor blocking agent that is eliminated almost exclusively by the kidney, and the mechanism responsible for the stereoselectivity is of interest in light of the very low metabolic clearance of atanolol are examined
Single dose pharmacokinetics of atenolol (AT) enantiomers was studied in human volunteers and in rats
Consider the first picture: a curved arrow is drawn from the highest priority ( 1) substituent to the lowest priority (4) substituent
After oral administration of 50 mg of racemic AT to humans, the areas under the plasma concentration–time curves (AUCs; mean ± SD) were 1640 ± 602 and 1860 ± 652 (ng/mL)h for the S(−)- and R(+)
Therefore, we investigated the effects on forearm blood flow (FBF) of brachial artery infusions of the (R)- and (S)- enantiomers of propranolol and atenolol (2, 10, and 50 micrograms/min each) and their inhibitory effects on isoprenaline (Iso)-induced vasodilatation by forearm venous occlusion plethysmography in 12 healthy subjects
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Different distribution of the two enantiomers between the associates and single molecules, caused by the effect of high concentration of a
In HPLC-based proteomics technique, the mixture of the cleaved peptides are bonded, separated sequentially on the multidimensional columns based on charge o
Retention times of R(-)-propranolol and S(+)-propranolol were 12
The proposed method was applied to the determination of enantiomers in pharmaceutical formulations, and no interference from any excipients was found
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Single dose pharmacokinetics of atenolol (AT) enantiomers was studied in human volunteers and in rats
Chemical compounds that come as mirror-image pairs are referred to by chemists as chiral or handed molecules
The enantiomers of atenolol interact with copper ions to produce positively charged complexes with different electrophoretic mobilities from the single molecules